![]() It should also be recognized that currently-available strains of high-potency cannabis and synthetic cannabinoid “spice” drugs can have adverse effects that are substantially worse than those associated with traditional strains of marijuana.Ĭannabis-derived materials such as marijuana and hashish contain a large number of chemical constituents, but the abuse-related euphorigenic effects result from the actions of THC on CB 1 receptors in the brain ( Le Foll & Goldberg, 2005 Williams and Kirkham, 2002). However, these societal trends should not obscure the fact that -like other medicinal/recreational drugs- cannabis has the potential to produce adverse effects on physical and mental health. In this chapter we describe: 1) animal models available for assessing the effect of potential medications on specific aspects of CUD 2) the main findings obtained so far with these animal models 3) the approaches used to assess potential medications in humans in laboratory experiments and clinical trials and 4) the effectiveness of several potential pharmacotherapies on the particular aspects of CUD modeled in these human studies.Ĭannabis has long been used for medicinal and recreational purposes, and both of these uses are becoming increasingly accepted legally and in public opinion. To achieve this, methods have been developed for screening and evaluating potential medications using animal models and controlled experimental protocols in human volunteers. ![]() Therefore, it would be beneficial to develop safe and effective medications for treating CUD. Many people have difficulty discontinuing use. ![]() However, cannabis has the potential to produce adverse physical and mental health effects and can result in cannabis use disorder (CUD) in a substantial percentage of both occasional and daily cannabis users. Cannabis use has been increasingly accepted legally and in public opinion.
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